Endocrine Abstracts

Introduction: Carney Complex (CNC) is a rare syndrome characterized by multiple endocrine and non-endocrine tumors, which may be accompanied by macular pigmentation of the skin. This is an autosomal dominant disorder with high penetrance and heterogeneous expression. It is caused by inactivating pathogenic variants in the PRKAR1A gene in over 70% of cases which encodes the regulatory type 1 alpha subunit of protein kinase A. Diagnosis is made by identifying specific criteria. ...

Introduction: Paragangliomas and pheochromocytomas (PGGs) are infrequent tumors of the autonomic nervous system that represent a diagnostic and therapeutic challenge. Management and follow-up of PGGs requires specialized knowledge and solid experience, which, given the rarity of these diseases, is available only in highly specialized centers. University Hospital La Fe (Spain) was designated a reference unit on Neuroendocrine Tumors by local sanitary authorities in 2018. The ai...